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Cat. No. Product Name CAS No. Information
CSN15708 Riociguat  625115-55-1 Riociguat acts as stimulator of soluble guanylate cyclase sGC that is used to treat ipulmonary hypertension
CSN15790 BPTES  314045-39-1 BPTES is an allosteric inhibitor of kidney-type glutaminase GLS with IC50 of 016 M
CSN15909 EW 7197  1352608-82-2 EW-7197 is a selective inhibitor of TGF- receptor ALK4 and ALK5 with IC50s of 13 nM and 11 nM.
CSN16034 RO4929097  847925-91-1 RO4929097 is an inhibitor of secretase the IC50s of A40 and notch are 14 nM and 5 nM respectively
CSN16359 OICR-9429  1801787-56-3 OICR-9429 is an antagonist of the interaction of WDR5 with peptide regions of MLL and Histone 3
CSN16614 Naringin  10236-47-2 Naringin is a flavanone glycoside, which exerts a variety of pharmacological effects such as antioxidant activity, blood lipid lowering, anticancer ac
CSN16708 Calcifediol  19356-17-3 Calcifediol is an active metabolite of vitamin D It can inhibit the secretion of parathyroid hormone with 2 nM and commonly used as an indicator of bo
CSN16776 Ketoconazole  65277-42-1 Ketoconazole is an imidazole anti-fungal agent which inhibits cyclosporine oxidase and testosterone 6 beta-hydroxylase with IC50 of 019 mM and 022 mM
CSN16910 GSK1324726A  1300031-52-0 GSK1324726A is an inhibitor of BET proteins BRD2 BRD3 BRD4 with IC50 of 41 nM 31 nM and 22 nM respectively
CSN17894 UNC0642  1481677-78-4 UNC0642 is a selective inhibitor of G9aGLP with IC50 of 15 nM
CSN17978 ETC-159  1638250-96-0 ETC-159 is a potent orally available PORCN inhibitor It inhibits -catenin reporter activity with an IC50 of 29 nM
CSN18277 Vipadenant  442908-10-3 Vipadenant is an adenosine antagonist with Ki of 13 nM and 68 nM for A2A and A1 respectively Vipadenant is a selective A2A receptor antagonist with K
CSN19682 GSK2982772  1622848-92-3 GSK2982772 is an inhibitor of receptor interacting protein 1 (RIP1) with IC50 of 16 nM and it is used for the treatment of inflammatory diseases.
CSN20539 IVA-337  927961-18-0 IVA-337 is a agonist of peroxisome proliferator-activated receptors PPAR which is widely used in the study of lung fibrosis and pulmonary hypertension
CSN21154 Lifitegrast  1025967-78-5 Lifitegrast is a novel small molecule integrin antagonist which can inhibit an integrin, lymphocyte function-associated antigen 1 (LFA-1), from bindin
CSN18830 Fevipiprant  872365-14-5 Fevipiprant is a selective potent reversible competitive CRTh2 antagonist with an in vitro dissociation constant KD value of 11nM at the CRTh2 recepto
CSN19708 GSK2193874  1336960-13-4 GSK2193874 is a selective transient receptor potential vanilloid 4 TRPV4 blocker with IC50 value of 004 M
CSN17916 GNE-9605  1536200-31-3 GNE-9605 is a selective and potent LRRK2 with IC50 value of 187 nM
CSN17256 RBC8  361185-42-4 RBC8 is an inhibitor of GTPases RalA and RalB with IC50 of 35 M in cell assay
CSN17980 AZD9496  1639042-08-2 AZD9496 is a selective antagonist of estrogen receptor Er IC50 028 nM
CSN19695 GLPG1690  1628260-79-6 GLPG1690 a first-in-class autotaxin ATX inhibitor with IC50 of 131 nM and Ki of 15 nMl is able to cause a sustained reduction of LPA levels in plasma
CSN15682 SB-705498  501951-42-4 SB-705498 is a selective antagonist of transient receptor potential vanilloid 1 TRPV1 with pIC50 of 71
CSN21065 GLPG1837  1654725-02-6 GLPG-1837 is a cystic fibrosis transmembrane conductance regulator CFTR potentiator1 shows enhanced efficacy on CFTR mutants harboring Class III mutat
CSN21094 AZD0364  2097416-76-5 AZD0364 is an ERK1 andor ERK2 kinase for the treatment of cancer
CSN21071 AMG-3969  1361224-53-4 AMG-3969 is a glucokinase-GKRP disruptor with IC50 value of 343nM and potently reverses the inhibitory effect of GKRP on GK activity.
CSN20461 WT161  1206731-57-8 WT161 selectively inhibits HDAC6 that exhibits effective anti-tumor activities in multiple myeloma
CSN17712 PF-4136309  1341224-83-6 PF-4136309 is a potent, Selective, and orally bioavailable CCR2 antagonist.
CSN18824 AZD0156  1821428-35-6 AZD0156 is a potent and selective inhibitors of ATM kinase with potential chemo-radio-sensitizing and antineoplastic activities
CSN18633 UNBS5162  956590-23-1 UNBS5162 is a naphthalimide and a hydrolysis product of UNBS3157 that decreases CXCL chemokine expression in experimental prostate cancers and the mea
CSN13891 PF-05089771  1235403-62-9 PF-05089771 is a Nav17 channel blocker with an IC50 of 86 nM
CSN19102 GNE-3511  1496581-76-0 GNE-3511 is a potent and selective zipper kinase (DLK, MAP3K12) inhibitors.
CSN19099 MGL-3196  920509-32-6 MGL-3196 is a selective thyroid hormone receptor agonist with EC50s of 0.21 and 3.74 M for TR and TR respectively.
CSN17993 PT-2385  1672665-49-4 PT2385 is an inhibitor of hypoxia inducible factor HIF-2 alpha with antineoplastic effect
CSN19143 PQR620  1927857-56-4 PRQ620 is a highly potent and selective mTORC1/2 inhibitor, shows anti-tumor effects in vitro and in vivo.
CSN20673 Leniolisib  1354690-24-6 Leniolisib is a potent and selective PI3K inhibitor currently in used for the treatment of immunodeficiency disorders.
CSN16223 GMX1778  200484-11-3 GMX1778 is a competitive NAMPT nicotinamide phosphoribosyltransferase inhibitor
CSN17357 Velpatasvir  1377049-84-7 Velpatasvir is an inhibitor of hepatitis C virus nonstructural protein 5A NS5A genotype 1 GT1 to GT6 replicons
CSN17164 PFI-1  1403764-72-6 PFI-1 is a highly selective BET bromodomain-containing protein inhibitor for BRD4 with IC50 of 022 M and for BRD2 with IC50 of 98 nM in a cell-free as
CSN22393 Elagolix Sodium  832720-36-2 Elagolix sodium is an antagonist of humanGnRH receptorGnRHR with IC50andKiof 025 nM and 37 nM respectively
CSN16482 AZD1981  802904-66-1 AZD1981 is a potent and selective CRTh2 antagonist and displaces radio-labelled PGD2 from human recombinant DP2 with high potency (pIC50 8.4).
CSN22610 BMS-309403  300657-03-8 BMS-309403 is an inhibitor of fatty acid binding protein 4 FABP4 with Ki of less than 2 nM that decreases fatty acid uptake in adipocytes in vitro
CSN16062 RAF265  927880-90-8 RAF265 is a pan-inhibitor that inhibits C-Raf B-Raf and B-Raf V600E with IC50 of 3 nM-60 nM It also shows inhibition on phosphorylation of VEGFR2 with
CSN21376 AM-0902  1883711-97-4 Potent and selective TRPA1 antagonist IC50 002 M for human TRPA1 Exhibits no siginificant activity against human TRPV1 or TRPV4 and rat TRPV1 TRPV3 o
CSN21371 LXH254  1800398-38-2 LXH254 is an ATP-competitive inhibitor of Raf with anti-proliferative activity Phase I
CSN21373 Risdiplam  1825352-65-5 Risdiplam is an orally administered centrally and peripherally distributed SMN2 pre-mRNA splicing modifier that increases survival motor neuron SMN pr
CSN23688 Tropifexor  1383816-29-2 Tropifexor is a potent agonist of FXR with EC50 of 026 nM
CSN23775 VTX-27  1321924-70-2 VTX-27 is an inhibitor of protein kinase C θ (PKC θ) and PKC δ with Kis of 0.08 nM and 16 nM, respectively.
CSN23877 Acrizanib  1229453-99-9 Acrizanib is an inhibitor of VEGFR-2 with IC50 of 17.4 nM for BaF3-KDR.
CSN24302 MK-7246  1218918-62-7 MK-7246 is a potent and selective CRTH2 antagonist with Ki value of 2.5nM.
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