||Riociguat acts as stimulator of soluble guanylate cyclase sGC that is used to treat ipulmonary hypertension
||BPTES is an allosteric inhibitor of kidney-type glutaminase GLS with IC50 of 016 M
||EW-7197 is a selective inhibitor of TGF- receptor ALK4 and ALK5 with IC50s of 13 nM and 11 nM.
||RO4929097 is an inhibitor of secretase the IC50s of A40 and notch are 14 nM and 5 nM respectively
||OICR-9429 is an antagonist of the interaction of WDR5 with peptide regions of MLL and Histone 3
||Naringin is a flavanone glycoside, which exerts a variety of pharmacological effects such as antioxidant activity, blood lipid lowering, anticancer ac
||Calcifediol is an active metabolite of vitamin D It can inhibit the secretion of parathyroid hormone with 2 nM and commonly used as an indicator of bo
||Ketoconazole is an imidazole anti-fungal agent which inhibits cyclosporine oxidase and testosterone 6 beta-hydroxylase with IC50 of 019 mM and 022 mM
||GSK1324726A is an inhibitor of BET proteins BRD2 BRD3 BRD4 with IC50 of 41 nM 31 nM and 22 nM respectively
||UNC0642 is a selective inhibitor of G9aGLP with IC50 of 15 nM
||ETC-159 is a potent orally available PORCN inhibitor It inhibits -catenin reporter activity with an IC50 of 29 nM
||Vipadenant is an adenosine antagonist with Ki of 13 nM and 68 nM for A2A and A1 respectively Vipadenant is a selective A2A receptor antagonist with K
||GSK2982772 is an inhibitor of receptor interacting protein 1 (RIP1) with IC50 of 16 nM and it is used for the treatment of inflammatory diseases.
||IVA-337 is a agonist of peroxisome proliferator-activated receptors PPAR which is widely used in the study of lung fibrosis and pulmonary hypertension
||Lifitegrast is a novel small molecule integrin antagonist which can inhibit an integrin, lymphocyte function-associated antigen 1 (LFA-1), from bindin
||Fevipiprant is a selective potent reversible competitive CRTh2 antagonist with an in vitro dissociation constant KD value of 11nM at the CRTh2 recepto
||GSK2193874 is a selective transient receptor potential vanilloid 4 TRPV4 blocker with IC50 value of 004 M
||GNE-9605 is a selective and potent LRRK2 with IC50 value of 187 nM
||RBC8 is an inhibitor of GTPases RalA and RalB with IC50 of 35 M in cell assay
||AZD9496 is a selective antagonist of estrogen receptor Er IC50 028 nM
||GLPG1690 a first-in-class autotaxin ATX inhibitor with IC50 of 131 nM and Ki of 15 nMl is able to cause a sustained reduction of LPA levels in plasma
||SB-705498 is a selective antagonist of transient receptor potential vanilloid 1 TRPV1 with pIC50 of 71
||GLPG-1837 is a cystic fibrosis transmembrane conductance regulator CFTR potentiator1 shows enhanced efficacy on CFTR mutants harboring Class III mutat
||AZD0364 is an ERK1 andor ERK2 kinase for the treatment of cancer
||AMG-3969 is a glucokinase-GKRP disruptor with IC50 value of 343nM and potently reverses the inhibitory effect of GKRP on GK activity.
||WT161 selectively inhibits HDAC6 that exhibits effective anti-tumor activities in multiple myeloma
||PF-4136309 is a potent, Selective, and orally bioavailable CCR2 antagonist.
||AZD0156 is a potent and selective inhibitors of ATM kinase with potential chemo-radio-sensitizing and antineoplastic activities
||UNBS5162 is a naphthalimide and a hydrolysis product of UNBS3157 that decreases CXCL chemokine expression in experimental prostate cancers and the mea
||PF-05089771 is a Nav17 channel blocker with an IC50 of 86 nM
||GNE-3511 is a potent and selective zipper kinase (DLK, MAP3K12) inhibitors.
||MGL-3196 is a selective thyroid hormone receptor agonist with EC50s of 0.21 and 3.74 M for TR and TR respectively.
||PT2385 is an inhibitor of hypoxia inducible factor HIF-2 alpha with antineoplastic effect
||PRQ620 is a highly potent and selective mTORC1/2 inhibitor, shows anti-tumor effects in vitro and in vivo.
||Leniolisib is a potent and selective PI3K inhibitor currently in used for the treatment of immunodeficiency disorders.
||GMX1778 is a competitive NAMPT nicotinamide phosphoribosyltransferase inhibitor
||Velpatasvir is an inhibitor of hepatitis C virus nonstructural protein 5A NS5A genotype 1 GT1 to GT6 replicons
||PFI-1 is a highly selective BET bromodomain-containing protein inhibitor for BRD4 with IC50 of 022 M and for BRD2 with IC50 of 98 nM in a cell-free as
||Elagolix sodium is an antagonist of humanGnRH receptorGnRHR with IC50andKiof 025 nM and 37 nM respectively
||AZD1981 is a potent and selective CRTh2 antagonist and displaces radio-labelled PGD2 from human recombinant DP2 with high potency (pIC50 8.4).
||BMS-309403 is an inhibitor of fatty acid binding protein 4 FABP4 with Ki of less than 2 nM that decreases fatty acid uptake in adipocytes in vitro
||RAF265 is a pan-inhibitor that inhibits C-Raf B-Raf and B-Raf V600E with IC50 of 3 nM-60 nM It also shows inhibition on phosphorylation of VEGFR2 with
||Potent and selective TRPA1 antagonist IC50 002 M for human TRPA1 Exhibits no siginificant activity against human TRPV1 or TRPV4 and rat TRPV1 TRPV3 o
||LXH254 is an ATP-competitive inhibitor of Raf with anti-proliferative activity Phase I
||Risdiplam is an orally administered centrally and peripherally distributed SMN2 pre-mRNA splicing modifier that increases survival motor neuron SMN pr
||Tropifexor is a potent agonist of FXR with EC50 of 026 nM
||VTX-27 is an inhibitor of protein kinase C θ (PKC θ) and PKC δ with Kis of 0.08 nM and 16 nM, respectively.
||Acrizanib is an inhibitor of VEGFR-2 with IC50 of 17.4 nM for BaF3-KDR.
||MK-7246 is a potent and selective CRTH2 antagonist with Ki value of 2.5nM.