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5-HT Receptor
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN26541 | ZK756326 2HCl | 1780259-94-0 | ZK-756326 is a potent, selective and non-peptide CCR8 chemokine receptor agonist. ZK 756326 inhibited the binding of the CCR8 ligand I-309 (CCL1), with an IC(50) value of 1.8 muM. ZK 756326 was a full agonist of CCR8, dose-responsively eliciting an increase in intracellular calcium and cross-desensitizing the response of the receptor to CCL1. |
| CSN12086 | Tiamenidine | 31428-61-2 | Thioridazine is an antipsychotic drug used in the treatment of schizophrenia and psychosis shows D4 selectivity or serotonin antagonism |
| CSN22076 | Temanogrel | 887936-68-7 | Temanogrel is a highly selective 5-HT2A receptor antagonist with Ki of 4.9 nM. |
| CSN11918 | Sertindole | 106516-24-9 | Sertindole, a neuroleptic, is one of the antipsychotic medications available, with a high affinity for dopamine D2, serotonin 5-HT2A, 5-HT2C, and α1-adrenergic receptors. |
| CSN21989 | SB-224289 HCl | 180084-26-8 | SB-224289 hydrochloride is a selective 5-HT1B receptor antagonist, with anxiolytic effect. |
| CSN26568 | SB-200646 | 143797-63-1 | SB-200646 is the first selective 5-HT2B/2C over 5-HT2A receptor antagonist with pKi values of 7.5, 6.9 and 5.2 for 5-HT2B, 5-HT2C and 5-HT2A, respectively. SB-200646 is orally active and has electrophysiological and anxiolytic properties in vivo[1][2]. |
| CSN26532 | Sarizotan | 351862-32-3 | Sarizotan (EMD 128130) is an orally active serotonin 5-HT1A receptor and dopamine receptor agonist. Sarizotan (EMD 128130) exhibits IC50 values of 6.5 nM (rat 5-HT1A), 0.1 nM (human 5-HT1A), 15.1 nM (rat D2), 17 nM (human D2), 6.8 nM (human D3) and 2.4 nM (human D4.2), respectively[1]. |
| CSN13491 | RS 127445 | 199864-87-4 | RS 127445 is a potent and selective antagonist at 5-HT2B receptor with pKi value of 95 |
| CSN33114 | Roluperidone | 359625-79-9 | Roluperidone is a 5-HT2A and sigma 2 receptor antagonist. |
| CSN17113 | Promethazine HCl | 58-33-3 | Promethazine HCl is the effective antagonist of the H1 receptor and moderate antagonist of mACh receptor. |
| CSN27301 | Phenylbiguanide | 102-02-3 | Phenylbiguanide is a 5-HT3 receptor selective agonist with an EC50 of 3.0±0.1 μM. |
| CSN18173 | Pardoprunox HCl | 269718-83-4 | Pardoprunox HCl is a partial dopamine D2 and D3 receptor agonist and serotonin 5-HT1A receptor agonist, D2 (pKi = 8.1) and D3 receptor (pKi = 8.6) partial agonist and 5-HT1A receptor (pKi = 8.5) full agonist. |
| CSN21782 | Pancopride | 121650-80-4 | Pancopride is a selective antagonist of 5-HT3 receptor. |
| CSN27303 | Org-12962 | 132834-56-1 | Org-12962 is a potent, selective and orally active 5-HT2C receptor agonist with a pEC50 value of 7.01. Org-12962 also exhibits high effacy for the 5-HT2A and 5-HT2B receptor with pEC50s of 6.38 and 6.28, respectively.Org-12962 displays antiaversive effects in a rat model of panic-like anxiety. |
| CSN23228 | NPS ALX Compound 4a 2HCl | 1781934-44-8 | NPS ALX Compound 4a dihydrochloride is a potent and selective 5-hydroxytryptamine6 (5-HT6) receptor antagonist, with an IC50 of 7.2 nM and a Ki of 0.2 nM . |
| CSN26151 | LY344864 racemate | 186543-64-6 | LY344864 racemate is the racemate form of LY344864. LY344864 is a selective receptor agonist with an affinity of 6 nM (Ki) at the recently cloned 5-HT1F receptor. |
| CSN21712 | Lintopride | 107429-63-0 | Lintopride is an antagonist of 5HT4 receptor and moderate antagonist of 5HT3. |
| CSN21711 | Lidanserin | 73725-85-6 | Lidanserin is antagonist of 5-HT2A and α1-adrenergic receptor. |
| CSN26570 | Lesopitron 2HCl | 132449-89-9 | Lesopitron dihydrochloride is a 5-HT1A receptor agonist potentially for the treatment of generalized anxiety disorder. |
| CSN23273 | Lecozotan | 434283-16-6 | Lecozotan is a potent and selective 5-HT(1A) receptor antagonist. It significantly potentiated the potassium chloride-stimulated release of glutamate and acetylcholine in the dentate gyrus of the hippocampus. It produced a significant improvement in task performance efficiency at an optimal dose (1 mg/kg p.o.) in aged rhesus monkeys. |
| CSN12998 | Lamotrigine | 84057-84-1 | Lamotrigine is a member of the sodium channel blocking class of antiepileptic drugs which can block L-, N-, and P-type calcium channels and has weak 5-HT3 receptor inhibition. |
| CSN21695 | Irindalone | 96478-43-2 | Irindalone is an antagonist of serotonin 5-HT2 receptor. |
| CSN27680 | GR 125743 | 148547-33-5 | GR 125743 is a novel 5-HT1B/1D receptor antagonist. |
| CSN26499 | Fiduxosin free base | 208993-54-8 | Fiduxosin is an alpha(1)-adrenoceptor antagonist with higher affinity for alpha(1A)-adrenoceptors and for alpha(1D)-adrenoceptors than for alpha(1B)-adrenoceptors. |
| CSN21600 | Deramciclane | 120444-71-5 | Deramciclane is an antagonist of 5-HT2A and inverse agonist of 5-HT2C receptor. It also functions as a GABA reuptake inhibitor. |
| CSN27302 | Dehydroaripiprazole | 129722-25-4 | Dehydroaripiprazole (OPC-14857) is an active metabolite of Aripiprazole. Aripiprazole is an antipsychotic agent and is metabolized by CYP3A4 and CYP2D6 forming mainly Dehydroaripiprazole. Dehydroaripiprazole has with antipsychotic activity equivalent to Aripiprazole. |
| CSN21594 | Dazopride | 70181-03-2 | Dazopride is an antiemetic agent which acts as a 5-HT3 receptor antagonist and 5-HT4 receptor agonist. |
| CSN33115 | CYR-101 HCl 2H2O | 1937215-88-7 | CYR-101 hydrochloride dihydrate is a 5-HT2A and sigma 2 receptor antagonist. |
| CSN32884 | AVN-211 | 1173103-84-8 | AVN-211 is a Novel and Highly Selective 5-HT6 Receptor Small Molecule Antagonist for the Treatment of Alzheimer's Disease. |
| CSN33129 | R-Azasetron | 2025360-90-9 | Arazasetron is an antiemetic which acts as a 5-HT3 receptor antagonist, pKi = 9.27. |
| CSN33130 | R-Arazasetron Besylate | 2025360-91-0 | Arazasetron besylate is an antiemetic which acts as a 5-HT3 receptor antagonist, pKi = 9.27. |
| CSN21450 | Abaperidone | 183849-43-6 | Abaperidone is an antagonist of 5-HT2A receptor and dopamine D2 receptor with IC50s of 6.2 and 17 nM respectively. |
| CSN24609 | 3-MPPI | 133399-65-2 | 3-MPPI is a very potent ligand for α1 sites and regulates smooth muscle contraction. The pKi values for α1B, α1D, α1A adrenoceptors are 8.74, 9.44, 9.57 respectively. It also binds to 5-HT1A sites (Ki = 50 nM). |
| CSN21566 | (Z)-Thiothixene | 3313-26-6 | (Z)-Thiothixene is serotonergic receptor antagonist. |
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