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5-HT Receptor

5-HT Receptor

Cat. No. Product Name CAS No. Information
CSN23195 WAY 208466 2HCl 1207064-61-6 WAY-208466 2HCl is a selective serotonin 5-HT6 receptor agonist.
CSN23171 Tropanserin 85181-40-4 Tropanserin is a selective 5-HT3 receptor antagonist.
CSN12086 Tiamenidine 31428-61-2 Thioridazine is an antipsychotic drug used in the treatment of schizophrenia and psychosis shows D4 selectivity or serotonin antagonism
CSN23100 SB 258719 HCl 1217674-10-6 Selective 5-HT7 antagonist
CSN23114 SGS 518 Oxalate 445441-27-0 Selective 5-HT6 antagonist
CSN23197 WAY 629 HCl 57756-44-2 Selective 5-HT2C agonist
CSN23140 Tandospirone HCl 99095-10-0 Selective 5-HT1A partial agonist
CSN23208 Zimelidine 2HCl 60525-15-7 Selective 5-HT uptake inhibitor
CSN23095 SB 215505 162100-15-4 SB215505 is a potent 5-HT2B/2C receptor antagonist (pKi values are 8.3, 7.66 and 6.77 for 5-HT2B, 5-HT2C and 5-HT2A respectively). It Increases wakefulness and motor activity in rats.
CSN23104 SB 399885 HCl 402713-81-9 SB-399885 hydrochloride is a 5-HT6 receptor antagonist.
CSN23105 SB 699551 864741-95-7 SB 699551 is a selective 5-ht5a receptor antagonist (pKi values are 8.3, < 6.0, < 6.0, < 6.0, < 5.5 and < 5.5 for 5-ht5a, 5-HT1B/D, 5-HT2A, 5-HT2C, 5-HT1A and 5-HT7 receptors respectively).
CSN23098 SB 243213 HCl 200940-23-4 SB 243213 hydrochloride is a selective and high-affinity 5-hydroxytryptamine (5-HT)2C receptor antagonist with a pKi of 9.37 and a pKb of 9.8 for human 5-HT2C receptor. SB 243213 hydrochloride has improved anxiolytic profile[1].
CSN23252 SB 243213 2HCl 1780372-25-9 SB 243213 dihydrochloride is an orally active, selective and high-affinity 5-hydroxytryptamine (5-HT)2C receptor antagonist with a pKi of 9.37 and a pKb of 9.8 for human 5-HT2C receptor. SB 243213 dihydrochloride has improved anxiolytic profile and has the potential for schizophrenia and motor disorders .
CSN23096 SB 221284 196965-14-7 SB 221284 is potent, selective 5-HT2C/2B receptor antagonist. SB 221284 are pKi values are 6.4, 7.9 and 8.6 for 5-HT2A, 2B and 2C receptors respectively.
CSN23094 SB 206553 HCl 1197334-04-5 SB 206553 HCl is a potent and selective 5-HT2B/5-HT2C receptor antagonist (rat 5-HT2B pA2 = 8.89, human 5-HT2C pKi = 7.92). It displays > 80-fold selectivity over all other 5-HT receptor subtypes and a variety of other receptors (pKi < 6).
CSN23093 SB 204741 152239-46-8 SB 204741 is potent and selective 5-HT2B receptor antagonist (pA2 = 7.95). It displays ≥ 135-fold selectivity over 5-HT2C (pKi = 5.82), 5-HT2A (pKi < 5.2), 5-HT1A, 1D, 1E, 5-HT3 and 5-HT4 receptors.
CSN23092 SB 204070 148688-01-1 SB 204070A is a highly selective 5-HT4 receptor antagonist.
CSN23091 SB 203186 HCl 207572-69-8 SB 203186 HCl is potent 5-HT4 receptor antagonist with high affinity for human atrial 5-HT4 receptors.
CSN23073 RS 102221 HCl 187397-18-8 RS-102221 HCl is a highly potent, selective 5-HT2C receptor antagonist.
CSN23066 Ro 04-6790 202466-68-0 Ro 04-6790 is a potent and selective 5-HT6 receptor antagonist (pKi values are 7.26 and 7.35 at rat and human 5-HT6 receptors respectively). Ro 04-6790 displays no affinity at a range of other receptors (IC50 > 10 μM).
CSN23099 SB 258585 HCl 1216468-02-8 Potent, selective 5-HT6 antagonist
CSN23130 SR 57227 HCl 77145-61-0 Potent and selective 5-HT3 agonist
CSN23193 WAY 161503 HCl 276695-22-8 Potent and selective 5-HT2C agonist
CSN27301 Phenylbiguanide 102-02-3 Phenylbiguanide is a 5-HT3 receptor selective agonist with an EC50 of 3.0±0.1 μM.
CSN27393 Paliperidone palmitate 199739-10-1 Paliperidone palmitate (9-Hydroxyrisperidone palmitate), an atypical long-acting antipsychotic agent, is an ester prodrug of Paliperidone. Paliperidone is a dopamine antagonist and 5-HT2A antagonist of the atypical antipsychotic class. Paliperidone palmitate shows efficacy against schizophrenia.
CSN27188 p-MPPI HCl 220643-77-6 p-MPPI is a novel 5-HT Receptor 1A receptor antagonist. It produced a significant and dose-related anxiolytic profile in male mice.
CSN27303 Org-12962 132834-56-1 Org-12962 is a potent, selective and orally active 5-HT2C receptor agonist with a pEC50 value of 7.01. Org-12962 also exhibits high effacy for the 5-HT2A and 5-HT2B receptor with pEC50s of 6.38 and 6.28, respectively.Org-12962 displays antiaversive effects in a rat model of panic-like anxiety.
CSN23228 NPS ALX Compound 4a 2HCl 1781934-44-8 NPS ALX Compound 4a dihydrochloride is a potent and selective 5-hydroxytryptamine6 (5-HT6) receptor antagonist, with an IC50 of 7.2 nM and a Ki of 0.2 nM .
CSN26151 LY344864 racemate 186543-64-6 LY344864 racemate is the racemate form of LY344864. LY344864 is a selective receptor agonist with an affinity of 6 nM (Ki) at the recently cloned 5-HT1F receptor.
CSN23273 Lecozotan 434283-16-6 Lecozotan is a potent and selective 5-HT(1A) receptor antagonist. It significantly potentiated the potassium chloride-stimulated release of glutamate and acetylcholine in the dentate gyrus of the hippocampus. It produced a significant improvement in task performance efficiency at an optimal dose (1 mg/kg p.o.) in aged rhesus monkeys.
CSN23084 S 14506 HCl 286369-38-8 Highly potent 5-HT1A agonist; displays unique binding mechanism
CSN23194 WAY 181187 Oxalate 1883548-85-3 High affinity and selective 5-HT6 agonist
CSN14586 Galanolactone 115753-79-2 Galanolactone, a natural product isolated and purified from the rhizomes of Zingiber officinale Roscoe with cytotoxic activity, has anti-5-HT effect, a diterpenoid isolated from ginger, is related to antagonism of 5-HT3 receptors, exerts anti-obesity effect through down regulation of adipogenic transcription factors and adipogenic marker genes, and inhibits nitric oxide production with IC(50) values ranging from 5.5 to 28.5 μM.
CSN27302 Dehydroaripiprazole 129722-25-4 Dehydroaripiprazole (OPC-14857) is an active metabolite of Aripiprazole. Aripiprazole is an antipsychotic agent and is metabolized by CYP3A4 and CYP2D6 forming mainly Dehydroaripiprazole. Dehydroaripiprazole has with antipsychotic activity equivalent to Aripiprazole.
CSN23783 AVN492 1220646-23-0 AVN492 is a selective antagonist of 5-HT6R with Ki of 91 pM.
CSN23078 RS 67506 HCl 168986-61-6 5-HT4 partial agonist
CSN23074 RS 23597-190 HCl 149719-06-2 5-HT4 antagonist
CSN23076 RS 39604 HCl 167710-87-4 5-HT4 antagonist
CSN23077 RS 56812 HCl 143339-12-2 5-HT3 partial agonist
CSN23090 SB 200646 HCl 143797-62-0 5-HT2C/2B antagonist
CSN23085 S 32212 HCl 847871-78-7 5-HT2C inverse agonist; α2-adrenoceptor antagonist
CSN23080 RU 24969 Hemisuccinate 66611-27-6 5-HT1A and 5-HT1B agonist
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