5-hydroxytryptamine Receptor | GPCR/G Protein|Neuronal Signaling| CSNpharm

5-HT Receptor

5-HT Receptor
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Cat. No.	Product Name	CAS No.	Information
CSN26541	ZK756326 2HCl	1780259-94-0	ZK-756326 is a potent, selective and non-peptide CCR8 chemokine receptor agonist. ZK 756326 inhibited the binding of the CCR8 ligand I-309 (CCL1), with an IC(50) value of 1.8 muM. ZK 756326 was a full agonist of CCR8, dose-responsively eliciting an increase in intracellular calcium and cross-desensitizing the response of the receptor to CCL1.
CSN12199	Vilazodone	163521-12-8	Vilazodone is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist currently under clinical evaluation for the treatment of major depression.
CSN12086	Tiamenidine	31428-61-2	Thioridazine is an antipsychotic drug used in the treatment of schizophrenia and psychosis shows D4 selectivity or serotonin antagonism
CSN22076	Temanogrel	887936-68-7	Temanogrel is a highly selective 5-HT2A receptor antagonist with Ki of 4.9 nM.
CSN21989	SB-224289 HCl	180084-26-8	SB-224289 hydrochloride is a selective 5-HT1B receptor antagonist, with anxiolytic effect.
CSN26568	SB-200646	143797-63-1	SB-200646 is the first selective 5-HT2B/2C over 5-HT2A receptor antagonist with pKi values of 7.5, 6.9 and 5.2 for 5-HT2B, 5-HT2C and 5-HT2A, respectively. SB-200646 is orally active and has electrophysiological and anxiolytic properties in vivo[1][2].
CSN26532	Sarizotan	351862-32-3	Sarizotan (EMD 128130) is an orally active serotonin 5-HT1A receptor and dopamine receptor agonist. Sarizotan (EMD 128130) exhibits IC50 values of 6.5 nM (rat 5-HT1A), 0.1 nM (human 5-HT1A), 15.1 nM (rat D2), 17 nM (human D2), 6.8 nM (human D3) and 2.4 nM (human D4.2), respectively[1].
CSN13491	RS 127445	199864-87-4	RS 127445 is a potent and selective antagonist at 5-HT2B receptor with pKi value of 95
CSN33114	Roluperidone	359625-79-9	Roluperidone is a 5-HT2A and sigma 2 receptor antagonist.
CSN17113	Promethazine HCl	58-33-3	Promethazine HCl is the effective antagonist of the H1 receptor and moderate antagonist of mACh receptor.
CSN27301	Phenylbiguanide	102-02-3	Phenylbiguanide is a 5-HT3 receptor selective agonist with an EC50 of 3.0±0.1 μM.
CSN18173	Pardoprunox HCl	269718-83-4	Pardoprunox HCl is a partial dopamine D2 and D3 receptor agonist and serotonin 5-HT1A receptor agonist, D2 (pKi = 8.1) and D3 receptor (pKi = 8.6) partial agonist and 5-HT1A receptor (pKi = 8.5) full agonist.
CSN21782	Pancopride	121650-80-4	Pancopride is a selective antagonist of 5-HT3 receptor.
CSN27393	Paliperidone palmitate	199739-10-1	Paliperidone palmitate (9-Hydroxyrisperidone palmitate), an atypical long-acting antipsychotic agent, is an ester prodrug of Paliperidone. Paliperidone is a dopamine antagonist and 5-HT2A antagonist of the atypical antipsychotic class. Paliperidone palmitate shows efficacy against schizophrenia.
CSN27188	p-MPPI HCl	220643-77-6	p-MPPI is a novel 5-HT Receptor 1A receptor antagonist. It produced a significant and dose-related anxiolytic profile in male mice.
CSN27303	Org-12962	132834-56-1	Org-12962 is a potent, selective and orally active 5-HT2C receptor agonist with a pEC50 value of 7.01. Org-12962 also exhibits high effacy for the 5-HT2A and 5-HT2B receptor with pEC50s of 6.38 and 6.28, respectively.Org-12962 displays antiaversive effects in a rat model of panic-like anxiety.
CSN23228	NPS ALX Compound 4a 2HCl	1781934-44-8	NPS ALX Compound 4a dihydrochloride is a potent and selective 5-hydroxytryptamine6 (5-HT6) receptor antagonist, with an IC50 of 7.2 nM and a Ki of 0.2 nM .
CSN26151	LY344864 racemate	186543-64-6	LY344864 racemate is the racemate form of LY344864. LY344864 is a selective receptor agonist with an affinity of 6 nM (Ki) at the recently cloned 5-HT1F receptor.
CSN21712	Lintopride	107429-63-0	Lintopride is an antagonist of 5HT4 receptor and moderate antagonist of 5HT3.
CSN21711	Lidanserin	73725-85-6	Lidanserin is antagonist of 5-HT2A and α1-adrenergic receptor.
CSN26570	Lesopitron 2HCl	132449-89-9	Lesopitron dihydrochloride is a 5-HT1A receptor agonist potentially for the treatment of generalized anxiety disorder.
CSN21695	Irindalone	96478-43-2	Irindalone is an antagonist of serotonin 5-HT2 receptor.
CSN27680	GR 125743	148547-33-5	GR 125743 is a novel 5-HT1B/1D receptor antagonist.
CSN26499	Fiduxosin free base	208993-54-8	Fiduxosin is an alpha(1)-adrenoceptor antagonist with higher affinity for alpha(1A)-adrenoceptors and for alpha(1D)-adrenoceptors than for alpha(1B)-adrenoceptors.
CSN25658	Elopiprazole	115464-77-2	Elopiprazole is an antipsychotic drug of the phenylpiperazine class.
CSN21600	Deramciclane	120444-71-5	Deramciclane is an antagonist of 5-HT2A and inverse agonist of 5-HT2C receptor. It also functions as a GABA reuptake inhibitor.
CSN27302	Dehydroaripiprazole	129722-25-4	Dehydroaripiprazole (OPC-14857) is an active metabolite of Aripiprazole. Aripiprazole is an antipsychotic agent and is metabolized by CYP3A4 and CYP2D6 forming mainly Dehydroaripiprazole. Dehydroaripiprazole has with antipsychotic activity equivalent to Aripiprazole.
CSN21594	Dazopride	70181-03-2	Dazopride is an antiemetic agent which acts as a 5-HT3 receptor antagonist and 5-HT4 receptor agonist.
CSN17079	Colfosceril Palmitate	63-89-8	Colfosceril palmitate is a drug used as a pulmonary surfactant. It is also a key conponent of LNP as an effective delivery vehicle of mRNA.
CSN21450	Abaperidone	183849-43-6	Abaperidone is an antagonist of 5-HT2A receptor and dopamine D2 receptor with IC50s of 6.2 and 17 nM respectively.
CSN24609	3-MPPI	133399-65-2	3-MPPI is a very potent ligand for α1 sites and regulates smooth muscle contraction. The pKi values for α1B, α1D, α1A adrenoceptors are 8.74, 9.44, 9.57 respectively. It also binds to 5-HT1A sites (Ki = 50 nM).
CSN21566	(Z)-Thiothixene	3313-26-6	(Z)-Thiothixene is serotonergic receptor antagonist.

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