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3C-like proteinase is a family of enzymes found in the Coronavirus polyprotein. It cleaves the polyprotein at two self-cleavage sites. It is a cysteine protease under clan PA, MEROPS classification C30. In coronaviruses, it is nonstructural protein number 5 (nsp5).

3CLpro

Cat. No. Product Name CAS No. Information
CSN12229 Zanamivir   139110-80-8 Zanamivir is the first of two registered neuraminidase inhibitors for the treatment and prophylaxis of influenza. Zanamivir could inhibit SARS-CoV-2 3CLpro main protease.
CSN19410 Tanshinone IIA   568-72-9 Tanshinone IIA is a naturally occuring cardioprotective agent which can inhibit NF-κB and AP-1 DNA binding and display antioxidant and anti-inflammatory properties. Tanshinone IIA showed inhibitory effect on PL(pro) with IC50 value of 1.6μM and less inhibitory effect on 3CLpro with IC50 value of 89.1μM.
CSN12435 Tanshinone I 568-73-0 Tanshinone I, an active principle isolated from the roots of Salvia miltiorrhiza (Danshen), is an inhibitor of type IIA human recombinant sPLA2 and rabbit recombinant cPLA2 with IC50s of 11 μM and 82 μM, respectively, is structurally similar to tanshinone IIA and may possess similar cytotoxic effects on tumor cells. Tanshinone I showed inhibitory effect on PL(pro) with IC50 value of 8.8μM and less inhibitory effect on 3CLpro with IC50 value of 38.7μM.
CSN11896 Saquinavir 127779-20-8 Saquinavir is an HIV Protease inhibitor used in antiretroviral therapy. Saquinavir could inhibit SARS-CoV-2 3CLpro main protease.
CSN16383 Hesperetin   520-33-2 Hesperetin is a flavanone extracted from the peel of citrus that exhibits inhibition of PDE4 and UGT. Hesperetin has antioxidative and anti-inflammatory effects as well. Hesperetin dose-dependently inhibited cleavage activity of the 3CLpro with IC50 value of 8.3μM in the cell-based assay.
CSN25342 GC376 1416992-39-6 GC376 is a 3CLpro (3C-like protease) inhibitor that shows promise in treating cats with certain presentations of FIP and has opened the door to targeted antiviral drug therapy.
CSN10460 Disulfiram   97-77-8 Disulfiram is a specific inhibitor of aldehyde-dehydrogenase (ALDH1), used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram acts as an allosteric inhibitor of MERS-CoV PLpro but as a competitive (or mixed) inhibitor of SARS-CoV PLpro.
CSN10276 Amentoflavone   1617-53-4 Amentoflavone is an inhibitor of human UDP-glucuronosyltransferases with anti-inflammatory, antioxidative, and neuroprotective effects and it can be isolated from the seeds of Ginkgo biloba L. Amentoflavone inhibited SARS-CoV 3CL(pro) with IC50 value of 8.3μM.
CSN17350 Aloe-Emodine   481-72-1 Aloe-emodin, a natural product isolated and purified from the root of Rheum palmatum L. with a specific in vitro and in vivo anti-neuroectodermal tumor activity, reduces the toxicity and ROS induced by both monomeric and oligomeric Aβ species, appears to have some protective effect not only against hepatocyte death but also on the inflammatory response subsequent to lipid peroxidation and has a strong non-carcinogenic stimulant-laxative action when applied to the skin, although it may increase the carcinogenicity of some kind of radiation. Aloe-Emodine dose-dependently inhibited cleavage activity of the 3CLpro with IC50 value of 366μM in the cell-based assay.
CSN25591 16-(R)-ML188 1417700-13-0 16-(R)-ML188 is a non-covalent SARS-CoV 3CLpro inhibitor with good enzyme and antiviral inhibitory activity.
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