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3C-like proteinase is a family of enzymes found in the Coronavirus polyprotein. It cleaves the polyprotein at two self-cleavage sites. It is a cysteine protease under clan PA, MEROPS classification C30. In coronaviruses, it is nonstructural protein number 5 (nsp5).

3CLpro

Cat. No. Product Name CAS No. Information
CSN12229 Zanamivir   139110-80-8 Zanamivir is the first of two registered neuraminidase inhibitors for the treatment and prophylaxis of influenza. Zanamivir could inhibit SARS-CoV-2 3CLpro main protease.
CSN25593 Theaflavin 3,3'-digallate 30462-35-2 Theaflavin-3,3'-digallate is a tea extract. Theaflavin-3,3'-digallate inhibited 3CLpro with IC50 value of 9.5μM in a fluorogenic substrate peptide assay.
CSN12034 Tanshinone IIB 17397-93-2 Tanshinone IIB (TSB), a natural product isolated and purified from the roots of Salvia miltiorrhiza, can significantly inhibit the DNA laddering, cytotoxicity and apoptosis of rat cortical neurons induced by staurosporine in a concentration-dependent manner. Tanshinone IIB showed inhibitory effect on PL(pro) with IC50 value of 10.7μM and less inhibitory effect on 3CLpro with IC50 value of 24.8μM.
CSN13608 Tanshinone IIA sulfonate sodium   69659-80-9 Tanshinone IIA sulfonate sodium is a water-soluble derivative of tanshinone IIA, which acts as an inhibitor of store-operated Ca2+entry (SOCE), and is used to treat cardiovascular disorders.
CSN19410 Tanshinone IIA   568-72-9 Tanshinone IIA is a naturally occuring cardioprotective agent which can inhibit NF-κB and AP-1 DNA binding and display antioxidant and anti-inflammatory properties. Tanshinone IIA showed inhibitory effect on PL(pro) with IC50 value of 1.6μM and less inhibitory effect on 3CLpro with IC50 value of 89.1μM.
CSN12435 Tanshinone I 568-73-0 Tanshinone I, an active principle isolated from the roots of Salvia miltiorrhiza (Danshen), is an inhibitor of type IIA human recombinant sPLA2 and rabbit recombinant cPLA2 with IC50s of 11 μM and 82 μM, respectively, is structurally similar to tanshinone IIA and may possess similar cytotoxic effects on tumor cells. Tanshinone I showed inhibitory effect on PL(pro) with IC50 value of 8.8μM and less inhibitory effect on 3CLpro with IC50 value of 38.7μM.
CSN19703 Remdesivir 1809249-37-3 Remdesivir is an nucleotide-analog antiviral prodrug. Remdesivir could inhibit SARS-CoV-2 3CLpro main protease.
CSN28746 Nirmatrelvir 2628280-40-8 PF-07321332 is an orally active 3CL protease inhibitor, binding covalently and directly to the catalytic cysteine (Cys145) residue of the enzyme. It works as an anti-SARS-CoV-2 drug.
CSN25590 Methyl tanshinonate 18887-19-9 Methyl tanshinonate showed inhibitory effect on PL(pro) with IC50 value of 9.2μM and less inhibitory effect on 3CLpro with IC50 value of 21.1μM.
CSN16383 Hesperetin   520-33-2 Hesperetin is a flavanone extracted from the peel of citrus that exhibits inhibition of PDE4 and UGT. Hesperetin has antioxidative and anti-inflammatory effects as well. Hesperetin dose-dependently inhibited cleavage activity of the 3CLpro with IC50 value of 8.3μM in the cell-based assay.
CSN19988 Herbacetin 527-95-7 Herbacetin, a natural product isolated and purified from the herbs of Equisetum hyemale L. It was found to efficiently block the enzymatic activity of SARS-CoV 3CLpro.
CSN25342 GC376 1416992-39-6 GC376 is a 3CLpro (3C-like protease) inhibitor that shows promise in treating cats with certain presentations of FIP and has opened the door to targeted antiviral drug therapy.
CSN16500 Dihydrotanshinone I 87205-99-0 Dihydrotanshinone I, a natural product isolated and purified from the roots of Salvia miltiorrhiza Bge., exhibits dose-dependent inhibition towards HLM-catalyzed propofol glucuronidation. Dihydrotanshinone I showed inhibitory effect on PL(pro) with IC50 value of 4.9μM and less inhibitory effect on 3CLpro with IC50 value of 14.4μM.
CSN16361 Cryptotanshinone   35825-57-1 Cryptotanshinone is a potent STAT3 inhibitor (IC50 =4.6 μM) and inhibits STAT3 Tyr705 phosphorylation in DU145 prostate cancer cells. Cryptotanshinone showed inhibitory effect on PL(pro) with IC50 value of 0.8μM and slight inhibitory effect on 3CLpro with IC50 value of 226.7μM.
CSN50790 CCF0058981 2708934-53-4 CCF0058981 is a ML300-derived, non-covalent SARS-CoV‑2 3CLpro inhibitor.
CSN17350 Aloe-emodin   481-72-1 Aloe-emodin, a natural product isolated and purified from the root of Rheum palmatum L. with a specific in vitro and in vivo anti-neuroectodermal tumor activity, reduces the toxicity and ROS induced by both monomeric and oligomeric Aβ species, appears to have some protective effect not only against hepatocyte death but also on the inflammatory response subsequent to lipid peroxidation and has a strong non-carcinogenic stimulant-laxative action when applied to the skin, although it may increase the carcinogenicity of some kind of radiation. Aloe-Emodine dose-dependently inhibited cleavage activity of the 3CLpro with IC50 value of 366μM in the cell-based assay.
CSN25594 3-isotheaflavin-3-gallate 220473-67-6 3-isotheaflavin-3-gallate is a tea extract. It inhibited 3CLpro with IC50 value of 7μM in a fluorogenic substrate peptide assay.
CSN27868 16-(S)-ML188   1417700-12-9 16-(S)-ML188 is a non-covalent SARS-CoV 3CLpro inhibitor with good enzyme and antiviral inhibitory activity.
CSN35888 (±)-Alliin 17795-26-5
CSN50497 Lufotrelvir 2468015-78-1
CSN62232 Niazinin 147821-57-6
CSN62389 (Rac)-X77 2144491-78-9
CSN62375 SARS-CoV-2-IN-10 2722634-95-7
CSN51374 Ensitrelvir 2647530-73-0
CSN51375 Ensitrelvir fumarate 2757470-18-9
CSN64922 YH-53 1471484-62-4
CSN67369 X77 2455518-33-7
CSN67707 SARS-CoV MPro-IN-1 2413716-71-7
CSN68548 SDZ 224-015 161511-45-1
CSN73846 INSCoV-614(1B) 2735704-33-1
CSN73852 INSCoV-601I(1) 2735704-19-3
CSN73851 INSCoV-600K(1) 2735704-15-9
CSN90043 SARS-CoV-2 3CLpro-IN-2 2765088-93-3
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