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Research Areas
Cancer
Cardiovascular Disease
Infection
Metabolic Disease
Neurological Disease
Immunology/Inflammation
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Staurosporine
Staurosporine is a prototypical potent ATP-competitive multikinase inhibitor with IC50 of 0.7, 7, 8.5, 6, 20 nM for PKC, PKA,PKG, p60v-src tyrosine protein kinase, CaM kinase II, respectively.
Alisertib
Alisertib is a selective Aurora inhibitor with IC50 of 12 nM with 200-fold higher selectivity for Aurora A than Aurora B
SCH772984
SCH772984 is a specific inhibitor of ERK12 with IC50 of 4 nM and 1 nM respectively
GSK343
GSK343 is a potent and selective EZH2 inhibitor with IC50 of 4 nM showing 60 fold selectivity against EZH1 and 1000 fold selectivity against other histone methyltransferases
BGJ398
BGJ-398 is a selective, pan-specific FGFR inhibitor with IC50 of 0.9, 1.4, and 1 nM for FGFR1, FGFR2, and FGFR3, respectively and > 40-fold selective for FGFR versus FGFR4 and VEGFR2, and little activity to Abl, Fyn, Kit, Lck, Lyn and Yes.
CP-673451
CP-673451 is a selective inhibitor of PDGFR with IC50 of 10 nM1 nM in cell-free assays exhibits 450-fold selectivity over other angiogenic receptors has antiangiogenic and antitumor activity
ABT-737
ABT-737 is a BH3 mimetic inhibitor of Bcl-xL Bcl-2 and Bcl-w with EC50 of 787 nM 303 nM and 1978 nM respectively showing no inhibition observed against Mcl-1 Bcl-B or Bfl-1
CPI-203
CPI 203 is a potent selective and cell permeable inhibitor of the bromodomain and extra terminal BET family protein BRD4 with an IC50 of 37 nM BRD4 -screen assay
I-BET-762
I-BET 762 is an inhibitor for BET proteins with IC50 of 35 nM.
GDC-0994
GDC-0994 is a selective inhibitor of ERK1/2 with IC50 value of 6.1 nM and 3.1 nM.
Featured ProductsMore
5-Methyl-2-Furaldehyde
7-Amino-4-Methylcoumarin
Methyleugenol
Perillartine
Phytic Acid Sodium
Pterostilbene
Riboflavin
Stevioside
Triacetylresveratrol
Selumetinib
Panobinostat
Cabazitaxel
Romidepsin
Alpelisib
Pracinostat
LY2090314
6-Maleimidohexanoic Acid N-Hydroxysuccinimide Ester
3,4-Dimethoxybenzoic Acid