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Cancer
Cardiovascular Disease
Infection
Metabolic Disease
Neurological Disease
Immunology/Inflammation
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DMOG
Dimethyloxallyl glycine is a cell permeable competitive inhibitor of HIF-PH HIF-1 prolyl hydroxylase
Veliparib
Veliparib is a potent inhibitor of PARP1 and PARP2 with Ki of 52 nM and 29 nM respectively
Crizotinib
Crizotinib is a potent inhibitor of c-Met and ALK with IC50 of 11 nM and 24 nM, respectivley.
Panobinostat
Panobinostat is a broad-spectrum HDAC inhibitor with IC50 of 5 nM in a cell-free assay.
ABT-199
ABT-199 is a Bcl-2-selective inhibitor with Ki of 0.01 nM, 4800-fold selective versus Bcl-xL and Bcl-w, and showing no activity to Mcl-1.
Tideglusib
Tideglusib is an irreversible GSK-3 inhibitor with IC50 of 5 nM and 60 nM for GSK-3WT (1 h preincubation) and GSK-3C199A (1 h preincubation), respectively.
Pracinostat
Pracinostat is a potent pan-HDAC inhibitor with IC50 of 40-140 nM with exception for HDAC6 and has no activity against the class III isoenzyme SIRT I.
SGI-1776
SGI-1776 free base is an ATP competitive inhibitor of Pim1 with IC50 of 7 nM in a cell-free assay 50- and 10-fold selective versus Pim2 and Pim3 also potent to Flt3 and haspin
SMI-4a
SMI-4a is a potent inhibitor of Pim1 with IC50 of 17 nM modestly potent to Pim-2 does not significantly inhibit any other serinethreonine- or tyrosine-kinases
Cabozantinib
Cabozantinib is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-134, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM11.3 nM6 nM, 14.3 nM and 7 nM, respectively.
Featured ProductsMore
5-Methyl-2-Furaldehyde
7-Amino-4-Methylcoumarin
Methyleugenol
Perillartine
Phytic Acid Sodium
Pterostilbene
Riboflavin
Stevioside
Triacetylresveratrol
Tetrahydrocurcumin
Docetaxel
Diosgenin
Phlorizin Dihydrate
Anethole Trithione
Rhein
Paclitaxel
6-Maleimidohexanoic Acid N-Hydroxysuccinimide Ester
3,4-Dimethoxybenzoic Acid